[Corticoids in therapy of rheumatic diseases yesterday--today--tomorrow]

The discovery of the suprarenal glands and their function is discussed. The complicated history of cortisone from the synthesis until its use as an antirheumatic is told. Pharmacotherapy with this physiologic hormone also caused serious side effects. Changing the molecular structure did not essentially solve this problem. Only after finding novel ways of application could these risks be reduced. The indications for therapy were further effectively reduced after understanding the mechanisms of action. Modern standards for corticoid therapy of rheumatoid arthritis are discussed. The important problem of corticoid osteoporosis and the myth of cortisone ulcers are also explained. The problems of coping with patient fears to cortisone are considered. Concurring drugs of cortisone and their special benefits are compared.