[Inception cohorts for spondyloarthropathies].

Area of Science:

• Rheumatology
• Immunology
• Genetics

Context:

• Spondyloarthropathies (SpA) are significant inflammatory rheumatic diseases with frequent onset in young patients.
• Key subtypes include Ankylosing spondylitis, reactive arthritis, and undifferentiated SpA, sharing clinical features and a strong association with HLA B27.
• Despite high prevalence, early diagnosis, treatment, and understanding of SpA's course, prognosis, and socioeconomic impact remain limited.

Purpose:

• To establish a cohort of early spondyloarthropathy patients to study disease course and outcomes.
• To specifically include juvenile SpA patients, recognizing differences in clinical presentation and early onset.
• To facilitate further research in diagnosis, therapy, immunology, and genetics of SpA within the MedNet framework.

Summary:

• The project focuses on creating an early spondyloarthropathy patient cohort to investigate disease progression and outcomes.
• Emphasis is placed on juvenile SpA due to its frequent onset in adolescence and distinct clinical characteristics compared to adult-onset AS.
• This cohort will support broader research initiatives on SpA, including infect-associated arthritides.

Impact:

• Enhance early diagnosis and therapeutic strategies for spondyloarthropathies.
• Improve understanding of the long-term prognosis and socioeconomic burden of SpA.
• Advance knowledge in SpA pathogenesis, immunology, and genetics, potentially leading to novel treatments.