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Delta infection in children with chronic viral hepatitis B

O S Makhmudov1, F I Inoyatova, B A Kadirov

  • 1Scientific Research Institute of Pediatrics of the Republic of Uzbekistan, Tashkent.

The Turkish Journal of Pediatrics
|January 1, 1997
PubMed

Insights

Hepatitis delta virus (HDV) superinfection is common in children with chronic hepatitis B, particularly those with chronic active hepatitis. HDV infection significantly increases the risk of hepatitis exacerbations in these young patients.

Area of Science:

  • Hepatology
  • Virology
  • Pediatrics

Background:

  • Chronic Hepatitis B (CHB) affects children worldwide.
  • Hepatitis Delta Virus (HDV) is a unique RNA virus that requires Hepatitis B Virus (HBV) for replication.
  • HDV superinfection can alter the clinical course of CHB.

Purpose of the Study:

  • To determine the incidence and clinical features of HDV infection in children with CHB.
  • To investigate the association between HDV infection and hepatitis exacerbations in pediatric CHB patients.

Main Methods:

  • A study of 300 children aged 1-14 years with CHB.
  • Detection of anti-delta antibodies to identify HDV infection.
  • Clinical assessment of hepatitis exacerbations.

Main Results:

  • Anti-delta antibodies were found in 14% (42/300) of children with CHB.
  • HDV infection was more prevalent in children with chronic active hepatitis and anti-HBe.
  • Children with anti-delta showed a higher rate of hepatitis exacerbations (11/12) compared to those without (4/12).

Conclusions:

  • HDV superinfection is a significant factor in pediatric CHB.
  • HDV infection is associated with an increased risk of hepatitis exacerbations in children with chronic active hepatitis and anti-HBe.
  • These findings suggest HDV plays a role in exacerbations of CHB in children.

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