Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-6 gene polymorphism and insulin sensitivity.

J M Fernández-Real1, M Broch, J Vendrell

  • 1Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr Josep Trueta, Spain. endocrino@htrueta.scs.es

Diabetes
|June 27, 2000
PubMed
Summary

A specific interleukin-6 (IL-6) gene variation is linked to improved insulin sensitivity and lower glucose levels in individuals with type 2 diabetes. This genetic factor influences key metabolic markers, suggesting a role in the acute-phase response.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Translated article] Patient With Neuropathic Ulcers and Morphea Treated With Apremilast.

Actas dermo-sifiliograficas·2025
Same author

Patient with Neuropathic Ulcers and Morphea Treated with Apremilast.

Actas dermo-sifiliograficas·2025
Same author

Analysis of apheresis outcomes in a cohort of Chilean patients treated with autologous stem cell transplantation: A single center real-world experience.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2024
Same author

A method to assess the quality of additive manufacturing metal powders using the triboelectric charging concept.

Scientific reports·2024
Same author

Detection of cytomegalovirus in bronchoalveolar lavage fluid from immunocompromised patients with pneumonitis by viral culture and DNA quantification.

Journal of virological methods·2023
Same author

Benefits in quality of life following an obstructive sleep apnea screening and treatment program in patients with acute ischemic stroke.

Revista de neurologia·2023

Area of Science:

  • Genetics
  • Metabolic Syndrome
  • Immunology

Background:

  • Type 2 diabetes and insulin resistance syndrome are potentially linked to the body's acute-phase response.
  • Interleukin-6 (IL-6) is a key cytokine mediating the acute-phase response.

Purpose of the Study:

  • To investigate the relationship between an interleukin-6 (IL-6) gene polymorphism and insulin sensitivity.
  • To explore how IL-6 genetic variations affect glucose metabolism and markers of inflammation.

Main Methods:

  • Studied an interleukin-6 (IL-6) gene polymorphism at position -174 (SfaNI genotype).
  • Assessed insulin sensitivity using an oral glucose tolerance test (OGTT) and calculated the insulin sensitivity index.
  • Measured serum glucose concentrations (AUCglucose), glycosylated hemoglobin, fasting insulin, and white blood cell count.

Related Experiment Videos

Main Results:

  • Individuals with the IL-6 C/C genotype (lower IL-6 levels) exhibited significantly lower AUCglucose, glycosylated hemoglobin, fasting insulin, and white blood cell counts compared to G allele carriers.
  • A notable gene dosage effect was observed for AUCglucose.
  • Insulin sensitivity index was increased in C/C individuals.
  • Serum cortisol binding globulin levels were lower in C/C subjects, indicating reduced IL-6 action.

Conclusions:

  • A polymorphism in the IL-6 gene significantly influences insulin sensitivity.
  • This IL-6 gene variation impacts postload glucose levels and peripheral white blood cell counts.
  • Findings suggest a genetic component to the interplay between inflammation and metabolic regulation in type 2 diabetes.