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Ribofuranosyl triazolone: a natural product herbicide with activity on adenylosuccinate synthetase following
P R Schmitzer1, P R Graupner, E L Chapin
1Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA.
Journal of Natural Products
|June 28, 2000
Abstract:
2,4-Dihydro-4-(beta-D-ribofuranosyl)-1,2,4(3H)-triazol-3-one (2) was identified as the principal phytotoxic component of a fermentation broth derived from an Actinomadura. The compound is a new natural product, but known by synthesis. Broad-spectrum herbicidal activity was demonstrated in greenhouse tests. Metabolite reversal studies suggested the target site was adenylosuccinate synthetase, which was confirmed by direct measurement of the activity of the 5'-phosphorylated derivative on the isolated enzyme.