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Related Experiment Videos

Ethyl glucuronide in human hair.

G Skopp1, G Schmitt, L Pötsch

  • 1Institute of Legal Medicine and Traffic Medicine, Heidelberg, Germany.

Alcohol and Alcoholism (Oxford, Oxfordshire)
|June 28, 2000
PubMed
Summary

Ethyl glucuronide (EtG) in hair and skin offers a longer detection window for alcohol consumption. While not always detectable, a positive EtG result reliably indicates recent alcohol use.

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Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Biomarker Research

Background:

  • Ethyl glucuronide (EtG) is a biomarker for alcohol consumption.
  • Current EtG detection in blood/urine has a limited retrospective window.
  • Keratinized tissues may offer extended detection periods for biomarkers.

Purpose of the Study:

  • To investigate the detectability of EtG in post-mortem keratinized tissues and perspiration stains.
  • To evaluate the potential of these matrices for a wider retrospective detection of alcohol consumption.
  • To correlate EtG presence with reported alcohol intake history.

Main Methods:

  • Collection of post-mortem hair, skin swabs, and stratum corneum samples.
  • Analysis of samples from individuals with documented alcohol misuse, regular drinking, and non-drinkers (children).

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  • Investigation for the presence of EtG in the collected specimens.

    • Main Results:

    • EtG was detected in most hair and stratum corneum samples from alcohol-consuming subjects.
    • EtG was also found in perspiration stains from alcohol consumers.
    • EtG levels were highly variable and potentially formed locally in small amounts.

    Conclusions:

    • EtG is not consistently detectable in keratinized tissues or perspiration stains from all alcohol drinkers.
    • A positive EtG finding in these matrices is strongly associated with recent alcohol consumption.
    • Keratinized tissues and perspiration stains show potential for retrospective EtG analysis, albeit with limitations.