Related Experiment Video
Updated: Oct 15, 2026
Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
Published on: November 2, 2015
Immediate-early gene expression in cerebral cortex following exposure to chronic-intermittent hypoxia
A L Sica1, H E Greenberg, S M Scharf
1Department of Medicine, Pulmonary and Critical Care Division, Long Island Jewish, Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA. asica@snet.net
Abstract:
Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical circuits that adaptively regulate sympathetic and cardiovascular activities.
