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Related Experiment Videos

Effects of hypnosis on diffuse noxious inhibitory controls.

G Sandrini1, I Milanov, S Malaguti

  • 1Department of Neurological Sciences, University Center for Adaptive Disorders and Headache, IRCCS, C. Mondino Foundation, University of Pavia, Via Palestro 3, 27100, Pavia, Italy. gsandrin@unipv.it

Physiology & Behavior
|June 28, 2000
PubMed
Summary

Hypnosis effectively reduces pain perception and nerve reflexes, particularly in individuals with high hypnotic susceptibility. These effects suggest hypnosis and diffuse noxious inhibitory controls (DNICs) may share pain-modulating pathways.

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Area of Science:

  • Neuroscience
  • Pain Management
  • Psychology

Background:

  • The precise neurophysiological mechanisms underlying hypnotic analgesia remain unclear.
  • Diffuse noxious inhibitory controls (DNICs) are known to reduce pain through counterstimulation.
  • Understanding how hypnosis interacts with pain modulation pathways is crucial for pain management.

Purpose of the Study:

  • To investigate the impact of hypnosis on pain perception and heterotopic nociceptive stimulation.
  • To compare the effects of hypnosis in individuals with high versus low hypnotic susceptibility.
  • To explore the relationship between hypnosis, DNICs, and descending pain inhibitory pathways.

Main Methods:

  • Administered hypnotic susceptibility scales to 50 healthy students.

Related Experiment Videos

  • Selected 20 participants (10 high, 10 low susceptibility) for controlled hypnotic analgesia sessions.
  • Measured nociceptive flexion reflex (RIII), subjective pain thresholds, and pain tolerance during nociceptive stimulation (cold-pressor test) with and without hypnosis.

    • Main Results:

    • Hypnosis significantly decreased subjective pain perception and the RIII reflex.
    • Hypnotic analgesia increased pain tolerance and reduced pain responses during the cold-pressor test.
    • These analgesic effects were observed exclusively in subjects with high hypnotic susceptibility.

    Conclusions:

    • Hypnotic susceptibility is a critical determinant of induced analgesia.
    • Both hypnosis and DNICs can modulate pain perception, potentially via shared descending inhibitory pathways.
    • Further research is needed to elucidate the precise interaction between hypnosis and endogenous pain control mechanisms.