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Related Experiment Videos

Leptin-induced decrease in food intake in chickens.

D M Denbow1, S Meade, A Robertson

  • 1Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0306, USA. denbowdm@vt.edu

Physiology & Behavior
|June 28, 2000
PubMed
Summary

Intracerebroventricular (i.c.v.) leptin injection reduced food intake in both fast-growing broiler and slow-growing Single Comb White Leghorn chickens. This suggests leptin acts centrally in birds to regulate appetite.

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Area of Science:

  • Animal Science
  • Neuroendocrinology
  • Avian Physiology

Background:

  • Leptin is a key hormone regulating energy balance in mammals.
  • Its role in avian species, particularly in growth variations, is less understood.
  • Understanding central appetite regulation in poultry is crucial for feed efficiency.

Purpose of the Study:

  • To investigate the central effects of leptin on food intake in different chicken breeds.
  • To determine if leptin's anorectic effect varies between fast-growing (broiler) and slow-growing (SCWL) chickens.
  • To assess the dose-response relationship of intracerebroventricular leptin in chickens.

Main Methods:

  • Intracerebroventricular (i.c.v.) injections of varying leptin doses were administered to broiler and SCWL chickens.

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  • Food and water intake were monitored post-injection.
  • Dose-dependent effects of leptin on consumption were analyzed.

    • Main Results:

    • Leptin administration via i.c.v. significantly decreased food intake in both broiler and SCWL chickens.
    • The effect was dose-dependent, with 10 microg being the most efficacious dose for both breeds.
    • Water intake remained largely unaffected, suggesting a specific effect on appetite rather than general malaise.

    Conclusions:

    • Leptin acts within the central nervous system of birds to suppress appetite.
    • The anorectic effect of leptin is conserved across different growth types in chickens.
    • These findings highlight leptin's potential role in central appetite regulation in avian species.