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Related Experiment Videos

Behavioral evidence for supersensitivity after chronic bromocriptine administration.

R C Smith, J R Strong, P B Hicks

    Psychopharmacology
    |February 28, 1979
    PubMed
    Summary

    Chronic bromocriptine (BRC) administration in mice led to tolerance in wheel running behavior and subsequent supersensitivity to dopamine agonists. This suggests potential clinical relevance for BRC and L-dopa combinations.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Chronic drug administration can induce complex neuroadaptive changes.
    • Dopamine agonists like bromocriptine (BRC) are used in treating various neurological conditions.
    • Understanding drug tolerance and supersensitivity is crucial for optimizing therapeutic strategies.

    Purpose of the Study:

    • To investigate behavioral tolerance and supersensitivity following chronic bromocriptine (BRC) or BRC + L-dopa administration in mice.
    • To assess the long-term effects of BRC on dopamine receptor sensitivity.

    Main Methods:

    • Chronic administration of bromocriptine (BRC) or BRC + L-dopa for 30 days in mice.
    • Measurement of wheel running (WR) behavior during drug administration.

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  • Assessment of apomorphine- and methylphenidate-(MP-)induced stereotyped gnawing post-treatment.

    • Main Results:

    • Tolerance to the initial depressant effect of BRC on WR developed within two weeks.
    • Increased WR behavior persisted for at least two days after BRC cessation.
    • Low doses of apomorphine and MP induced significantly greater stereotyped gnawing in BRC-treated groups, indicating dopaminergic supersensitivity.

    Conclusions:

    • Chronic BRC administration induces tolerance to its own effects and behavioral supersensitivity to dopamine agonists.
    • These findings highlight the neuroadaptive potential of BRC.
    • The observed dopaminergic supersensitivity may inform the clinical application of BRC, particularly in combination therapies with L-dopa.