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3-acetylaltholactone and related styryl-lactones, mitochondrial respiratory chain inhibitors
E Peris1, E Estornell, N Cabedo
1Departamento de Farmacología, Universidad de Valencia, Spain.
Phytochemistry
|June 28, 2000
Abstract:
A novel furano-pyrone, 3-acetylaltholactone, and two other known styryl-lactones, altholactone and 5-acetoxyisogoniothalamin oxide, have been isolated from Goniothalamus arvensis (Annonaceae) stem bark. We report here the isolation and structural elucidation of these compounds with furane-pyrone and styryl-pyrone skeletons, postulating also for the first time their mechanism of cytotoxicity based on inhibition on mammalian mitochondrial respiratory chain.