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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Lipoprotein (a), cholesterol and triglycerides in women with venous thromboembolism

M D McColl1, N Sattar, J Ellison

  • 1Department of Haematology, Royal Infirmary, Glasgow, UK. mmccoll1@aol.com

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|June 28, 2000
PubMed

Insights

Lipoprotein (a) is not significantly linked to venous thromboembolism (VTE) in young women. However, obesity may increase VTE risk through higher triglyceride levels, impacting clotting factors.

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Metabolic Disorders

Background:

  • Venous thromboembolism (VTE) is a significant health concern, particularly in younger women.
  • Obesity is a known risk factor for VTE, but the underlying mechanisms require further elucidation.
  • Lipid profiles, including lipoprotein (a), are being investigated for their role in VTE pathogenesis.

Purpose of the Study:

  • To investigate the association between plasma lipoprotein (a) levels and objectively confirmed venous thromboembolism (VTE) in women aged 50 years or younger.
  • To examine differences in lipid profiles (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride) between VTE cases and controls.
  • To assess the influence of body mass index (BMI) on these associations.

Main Methods:

  • A case-control study involving 62 women with VTE and 98 age-matched female controls.
  • Measurement of plasma concentrations of lipoprotein (a), total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride.
  • Statistical analysis to compare lipid profiles and assess the impact of BMI.

Main Results:

  • Cases had significantly higher mean BMI and plasma triglyceride levels compared to controls.
  • Cases exhibited significantly lower total cholesterol and HDL-cholesterol levels.
  • After adjusting for BMI, total cholesterol and LDL-cholesterol remained significantly lower in cases.
  • No significant difference in mean plasma lipoprotein (a) levels was observed between VTE cases and controls.

Conclusions:

  • Plasma lipoprotein (a) does not appear to be significantly associated with the development of VTE in young women.
  • The increased VTE risk in obese individuals may be partly mediated by hypertriglyceridaemia.
  • Hypertriglyceridaemia's potential effects on coagulation factors and inhibitors warrant further investigation in the context of VTE risk.

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