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Desmoplastic leiomyosarcoma of the skin
C Diaz-Cascajo1, S Borghi, W Weyers
1Center for Dermatopathology, Freiburg, Germany.
The American Journal of Dermatopathology
|June 28, 2000
Summary
This report describes desmoplastic leiomyosarcoma of the skin, a rare cutaneous tumor with sparse cells in dense stroma. It can be mistaken for other sclerotic skin conditions or desmoplastic tumors.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Cutaneous leiomyosarcoma is a rare soft tissue sarcoma.
- Sclerotic variants are exceptionally uncommon, with only one prior report.
Observation:
- Two cases of cutaneous leiomyosarcoma with sparse neoplastic cells and abundant sclerotic stroma are presented.
- The distinctive morphology resembles other desmoplastic skin tumors.
Findings:
- The authors propose the term 'desmoplastic leiomyosarcoma of the skin' for this entity.
- Sparse cellularity and abundant stroma can lead to misdiagnosis, particularly in small biopsies.
Implications:
- This entity should be considered in the differential diagnosis of sclerotic skin lesions.
- Distinguishing it from radiation dermatitis and other desmoplastic tumors (melanocytic nevus, melanoma, squamous cell carcinoma) is crucial.