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Related Experiment Videos

Dermatofibroma with diffuse eosinophilic infiltrate.

S Aiba1, T Terui, H Tagami

  • 1Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.

The American Journal of Dermatopathology
|June 28, 2000
PubMed
Summary
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This study reports a rare case of dermatofibroma in an 8-year-old boy featuring eosinophilic infiltration. This finding expands the known cellular composition of dermatofibromas, a common benign skin tumor.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Dermatofibroma, a common benign fibrous histiocytoma, typically presents with fibroblastic, histiocytic, and multinucleated cells.
  • Lymphoid cell infiltration (B cells and T cells) is a characteristic feature at the border of dermatofibromas.

Observation:

  • This report details a unique case of dermatofibroma in an 8-year-old boy located on the pretibial region.
  • Microscopic examination revealed an unusual diffuse eosinophilic infiltration within the tumor.

Findings:

  • The dermatofibroma was histologically characterized by histiocytic cells and mature collagen.
  • Immunoreactivity to anti-factor XIIIa antibody confirmed the diagnosis of dermatofibroma.

Implications:

  • This case highlights the potential for eosinophilic infiltration in dermatofibromas, a finding not previously documented.

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  • It expands the differential diagnosis for eosinophilic skin lesions and contributes to understanding dermatofibroma heterogeneity.