Related Experiment Video
Updated: Aug 28, 2026
GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
Published on: July 17, 2011
The GABA-B antagonist CGP 36742 prevent PTZ-kindling-provoked amnesia in rats
M G Genkova-Papazova1, B Petkova, N Shishkova
1Laboratory CNS Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. bl. 23, 1113, Sofia, Bulgaria. books@iph.bio.acad.bg
Abstract:
Deficit in active and inhibitory avoidance behaviour has been found in pentylenetetrazole (PTZ)-kindled rats. This supports the view that memory deficit is an integral part of epilepsy. In the present study we examined the effect of the GABA B antagonist CGP 36742 on memory deficit induced by PTZ-kindling in shuttle-box- and step-down-trained rats. The retention in CGP 36742-treated animals was significantly improved compared to the kindled controls. The mechanisms of action of CGP 36742 is considered. The favourable effect of the GABA B antagonist in cases of amnesia provoked by PTZ-kindling might be of interest in clinical practice.
