Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Regeneration after delayed nerve suture].

O Guntinas-Lichius1, M Streppel, D N Angelov

  • 1Klinik und Poliklinik für HNO-Heilkunde, Universität zu Köln.

HNO
|June 29, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laryngo- rhino- otologie·2026
Same author

Laryngo- rhino- otologie·2026
Same author

Laryngo- rhino- otologie·2026
Same author

[Use of Omalizumab-biosimilars for CRSwNP in the German Health Care System - a Position Paper of the German Societies for Allergy AeDA and ORL DGHNO-KHC].

Laryngo- rhino- otologie·2026
Same author

Deciding whether to do elective neck dissection in patients with salivary gland tumors with no evidence of neck lymph node metastasis.

European annals of otorhinolaryngology, head and neck diseases·2025
Same author

The German cochlear implant registry: one year experience and first results on demographic data.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2024

A short delay in nerve suture, specifically 14 days, significantly improved axonal regeneration and reinnervation after nerve injury in rats. Even a 224-day delay allowed for some nerve repair.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Surgical Innovation

Context:

  • Nerve injuries often require surgical repair, but the optimal timing for nerve sutures remains unclear.
  • Understanding the impact of delayed nerve anastomosis is crucial for improving patient outcomes.
  • Axonal regeneration and reinnervation are complex processes influenced by various factors, including surgical intervention timing.

Purpose:

  • To investigate the effect of delayed hypoglossal-facial nerve anastomosis (HFA) on axonal regeneration and functional recovery.
  • To compare the outcomes of immediate HFA with 14-day and 224-day delayed HFA in a rat model.
  • To quantify the extent of neuronal reinnervation and muscle function after different time delays.

Summary:

  • This study utilized a rat model to assess axonal regeneration following delayed hypoglossal-facial nerve anastomosis (HFA).

Related Experiment Videos

  • Results indicated that a 14-day delay in HFA significantly enhanced axonal reinnervation compared to immediate repair (104% vs. 75%).
  • Even a 224-day delay permitted substantial, albeit reduced, reinnervation (61%), suggesting nerve repair remains possible after prolonged delays.

    • Impact:

    • Short-term delays (14 days) in nerve suture can optimize axonal regeneration and functional recovery after nerve lesions.
    • These findings may inform clinical decision-making regarding the timing of nerve repair surgeries.
    • Further research could explore the molecular mechanisms underlying enhanced regeneration with delayed nerve suturing.