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Related Experiment Videos

[Insulin resistance. Frequently administration errors are the source].

T Rendschmidt1, H J Lüddeke, R Renner

  • 1III. Medizinische Abteilung für Endokrinologie, Stoffwechsel und Angiologie, Krankenhaus München-Bogenhausen. mail@rendschmidt.de

MMW Fortschritte Der Medizin
|June 29, 2000
PubMed
Summary
This summary is machine-generated.

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Insulin resistance encompasses physiological and pathological changes. Effective treatment for severe cases involves high-dose intravenous insulin, potentially allowing a return to subcutaneous insulin therapy.

Area of Science:

  • Endocrinology
  • Metabolic Disorders

Background:

  • Insulin resistance presents as both physiological (e.g., puberty, aging) and pathological states.
  • Pathological insulin resistance includes genetic (Type A) and autoimmune (Type B) forms, alongside a growing concern in type 2 diabetes.

Observation:

  • A significant increase in insulin requirement is noted in type 2 diabetics, suggesting subcutaneous insulin resistance.
  • This condition can be diagnosed through various testing methods.

Findings:

  • The primary treatment involves high-dose, carefully profiled intravenous insulin administration to overcome resistance.
  • Successful intravenous insulin therapy can enable a transition back to adequately dosed subcutaneous insulin.

Implications:

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  • This approach offers a viable strategy for managing severe insulin resistance in type 2 diabetes.
  • Understanding and treating subcutaneous insulin resistance is crucial for improving glycemic control.