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Updated: Aug 12, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
De novo design and structural characterization of proteins and metalloproteins
W F DeGrado1, C M Summa, V Pavone
1Johnson Research Foundation, Pennsylvania, Philadelphia, USA. wdegrado@mail.med.upenn.edu
Abstract:
De novo protein design has recently emerged as an attractive approach for studying the structure and function of proteins. This approach critically tests our understanding of the principles of protein folding; only in de novo design must one truly confront the issue of how to specify a protein's fold and function. If we truly understand proteins, it should be possible to design receptors, enzymes, and ion channels from scratch. Further, as this understanding evolves and is further refined, it should be possible to design proteins and biomimetic polymers with properties unprecedented in nature.
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