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Related Experiment Videos

Quetiapine (Seroquel) concentrations in seven postmortem cases.

D T Anderson1, K L Fritz

  • 1Los Angeles County Department of Coroner, California 90033, USA.

Journal of Analytical Toxicology
|June 29, 2000
PubMed
Summary

Quetiapine, an antipsychotic, was detected in seven postmortem cases. This study details its tissue distribution in deceased individuals, providing crucial forensic toxicology data.

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Area of Science:

  • Forensic Toxicology
  • Pharmacology

Background:

  • Quetiapine, a dibenzothiazepine derivative, is an antipsychotic medication approved in the US since 1997.
  • Basic drug screens can detect quetiapine, indicating its potential relevance in toxicological analyses.

Observation:

  • The Los Angeles County Department of Coroner Toxicology Laboratory identified quetiapine in seven postmortem cases.
  • Analytical methods included gas chromatography with nitrogen-phosphorus and mass spectrometry detection.
  • Established linearity from 0.10 to 3.0 mg/L with a limit of quantitation at 0.10 mg/L.

Findings:

  • Postmortem tissue distribution data for quetiapine were determined.
  • Concentrations varied across specimens: heart blood (0.10-49 mg/L), femoral blood (0.10-1.4 mg/L), liver (0.10-112 mg/kg), spleen (4.0 mg/kg), urine (0-3.0 mg/L), bile (0.60-7.5 mg/L), and gastric contents (<0.01-18 mg total).

Implications:

  • This is the first reported study detailing quetiapine presence and distribution in postmortem specimens.
  • Findings contribute valuable data for forensic toxicologists investigating quetiapine-related cases.
  • Establishes analytical parameters for quetiapine detection in postmortem toxicology.

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