Jove
Visualize
Contact Us

Related Experiment Videos

Influenza virus genetics.

E G Brown1

  • 1Dept. of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario, Canada.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 29, 2000
PubMed
Summary

Genetic analysis of influenza A virus reveals insights into host interactions and pathogenesis. Understanding viral genes and host factors is crucial for controlling influenza zoonosis and developing new antiviral therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immature teratoma of the ovary in children and adolescents: A multi-institutional study of characteristics and management.

Gynecologic oncology·2026
Same author

Immature teratoma of the ovary with microscopic yolk sac tumor in children and adolescents: A multi-institutional study.

Gynecologic oncology·2026
Same author

Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem.

Frontiers in immunology·2012
Same author

Weight reduction of obese women of college age; clinical results and basal metabolism.

Journal of the American Dietetic Association·2010
Same author

Weight reduction of obese women of college age; nitrogen, calcium, and phosphorus retentions of young women during weight reduction.

Journal of the American Dietetic Association·2010
Same author

Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008.

Veterinary microbiology·2010
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Virology
  • Genetics
  • Immunology

Background:

  • Influenza A virus replication is well-studied in vitro, but genetic control of virus-host interactions in disease remains less understood.
  • Influenza has a segmented genome, enabling reassortment and providing a valuable genetic tool for studying viral evolution and biology.
  • Influenza infection is a zoonosis originating from avian strains, requiring adaptation to human hosts for disease transmission.

Purpose of the Study:

  • To provide an overview of the genetic analysis of influenza A virus biology.
  • To present the functional map of individual influenza A virus genes and current understanding of pathogenesis.
  • To discuss host-range determinants, antiviral drugs, and potential targets for future therapies.

Main Methods:

  • Review of existing literature on influenza A virus genetics, pathogenesis, and host interactions.
  • Analysis of the functional roles of individual viral genes.
  • Examination of host-specific interactions affecting viral receptor binding and ribonucleocapsid function.

Main Results:

  • A functional map of influenza A virus genes and current insights into pathogenesis are presented.
  • Reassortant viruses are a key genetic tool for studying influenza evolution and biology.
  • Host-range restriction is primarily mediated by specific interactions between viral components and host factors.

Conclusions:

  • Understanding the genetic basis of influenza virus-host interactions is critical for addressing pathogenesis and disease.
  • Genetic reassortment plays a significant role in influenza virus evolution and adaptation.
  • Knowledge of viral genetics and host factors informs the development of antiviral strategies and drug resistance management.

Related Experiment Videos