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Related Experiment Videos

Body mass index and delayed conception: a European Multicenter Study on Infertility and Subfecundity.

F Bolúmar1, J Olsen, M Rebagliato

  • 1Department of Public Health, University Miguel Hernández, Alicante, Spain.

American Journal of Epidemiology
|June 29, 2000
PubMed
Summary

Obesity and underweight increase time to conception for female smokers. Non-smoking women with these body mass index (BMI) categories did not experience conception delays.

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Area of Science:

  • Reproductive Health
  • Public Health
  • Epidemiology

Background:

  • Obesity is a growing health concern in developed nations.
  • Limited research exists on obesity's impact on subfertility, with prior studies focusing on specific groups and yielding inconsistent results.
  • Existing studies often concentrated on ovulatory dysfunction, leaving a gap in understanding BMI's broader effect on conception.

Purpose of the Study:

  • To investigate the association between body mass index (BMI) and delayed conception in a large European population.
  • To determine if obesity or underweight status influences the time it takes for women to conceive.
  • To explore potential moderating effects of smoking on the BMI-fertility relationship.

Main Methods:

  • A population-based survey of 4,035 pregnant women across five European countries conducted in 1992.

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  • Women were recruited from antenatal clinics/hospitals after 20 weeks gestation.
  • Delayed conception was defined as over 9.5 months of unprotected intercourse; BMI and smoking status were key variables analyzed.

    • Main Results:

    • For women who smoke, obesity (BMI ≥ 30 kg/m²) was strongly associated with delayed conception (OR = 11.54).
    • Underweight women (BMI < 20 kg/m²) who smoke also showed an increased risk of delayed conception (OR = 1.70).
    • No significant association between BMI categories (obesity or underweight) and delayed conception was observed in non-smoking women.

    Conclusions:

    • In women who achieve pregnancy, smoking is a critical factor linking underweight or obesity to longer conception times.
    • The findings suggest that smoking may exacerbate the negative effects of abnormal BMI on fertility.
    • Public health initiatives addressing both smoking cessation and healthy weight management may be beneficial for women trying to conceive.