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Transcriptional control: imprinting insulation
1Sangamo Biosciences Inc, Point Richmond Tech Center, Richmond, CA 94804,USA. awolffe@sangamo.com
Current Biology : CB
|June 30, 2000
Abstract:
Recent studies on the transcriptional regulation of two linked, imprinted genes, Igf2 and H19, have provided evidence for a novel mechanism of epigenetic control. DNA methylation controls the activity of an insulator element located between the two linked genes by regulating the binding of the zinc-finger protein CTCF.