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Integrin-collagen complex: a metal-glutamate handshake
1Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK.
Structure (London, England : 1993)
|June 30, 2000
Abstract:
The recently determined crystal structure of the complex between an integrin I domain and a synthetic collagen peptide shows a collagen triple-helix engaged in specific macromolecular recognition and binding. This structure confirms a previously proposed binding mechanism for integrin I domains and has important implications for integrin activation and signalling.