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Do sex and hormonal status influence choroidal circulation?

M Centofanti1, S Bonini, G Manni

  • 1Cattedra di Clinica Oculistica, Università di Roma Tor Vergata, Fondazione GB Bietti per l'Oftalmologia, Rome, Italy. mcentofanti@lycosmail.com

The British Journal of Ophthalmology
|June 30, 2000
PubMed
Summary

Premenopausal females exhibit higher pulsatile ocular blood flow (POBF) and pulse amplitude (PA) compared to males and post-menopausal women, indicating sex and hormones influence choroidal circulation.

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Area of Science:

  • Ophthalmology
  • Cardiovascular Physiology
  • Endocrinology

Background:

  • Ocular blood flow is crucial for retinal health.
  • Understanding factors influencing ocular hemodynamics is vital for diagnosing and managing eye conditions.
  • Pulse amplitude (PA) and pulsatile ocular blood flow (POBF) are key indicators of ocular hemodynamics.

Purpose of the Study:

  • To investigate the relationship between pulse amplitude (PA), pulsatile ocular blood flow (POBF), and sex and hormonal status.
  • To determine if sex and hormonal status significantly affect choroidal circulation.

Main Methods:

  • Ocular blood flow tonography was used to measure POBF and PA in 76 healthy subjects (32 males, 44 females).
  • Females were categorized into premenopausal (17-42 years) and post-menopausal (≥55 years) groups.

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  • Age-matched male groups served as controls.

    • Main Results:

    • Premenopausal females showed significantly higher POBF and PA rates compared to age-matched males.
    • Post-menopausal females exhibited lower POBF and PA rates than premenopausal females.
    • These findings suggest a significant difference in ocular hemodynamics based on sex and menopausal status.

    Conclusions:

    • Sex and hormonal status significantly influence choroidal circulation.
    • Hormonal changes, particularly estrogen levels, may play a role in regulating ocular blood flow.
    • Further research is warranted to explore the clinical implications of these findings in ophthalmic diseases.