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Related Experiment Videos

Does perchlorate in drinking water affect thyroid function in newborns or school-age children?

C Crump1, P Michaud, R Téllez

  • 1ICF Consulting, Seattle, Wash., USA. kccrump@u.washington.edu

Journal of Occupational and Environmental Medicine
|June 30, 2000
PubMed
Summary

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Perchlorate in drinking water did not suppress thyroid function in children or newborns, even at high levels. Study findings do not support concerns about perchlorate

Area of Science:

  • Environmental Health
  • Endocrinology
  • Public Health

Background:

  • Perchlorate is known to inhibit iodide uptake by the thyroid gland.
  • Previous studies indicate thyroid suppression at doses of 200 mg/day or greater.
  • The impact of perchlorate in drinking water on thyroid function in children is not well-established.

Purpose of the Study:

  • To investigate the effects of varying perchlorate concentrations in drinking water on thyroid function in newborns and school-age children.
  • To assess thyroid-stimulating hormone (TSH) levels and goiter prevalence in relation to perchlorate exposure.
  • To evaluate the risk of congenital hypothyroidism in areas with different perchlorate levels.

Main Methods:

  • A cross-sectional study involving 162 school-age children and 9784 newborns in three Chilean cities with distinct perchlorate levels (Taltal: 100-120 µg/L, Chañaral: 5-7 µg/L, Antofagasta: <4 µg/L).

Related Experiment Videos

  • Adjusted analysis for age, sex, and urinary iodine levels.
  • Monitoring of thyroid-stimulating hormone (TSH) levels and assessment of goiter prevalence and congenital hypothyroidism cases.

    • Main Results:

    • No significant differences in TSH levels or goiter prevalence were observed among schoolchildren residing in Taltal or Chañaral compared to Antofagasta.
    • No presumptive cases of congenital hypothyroidism were detected in Taltal or Chañaral, while seven cases were identified in Antofagasta.
    • Neonatal TSH levels were lower in Taltal compared to Antofagasta, an unexpected finding not considered clinically significant.

    Conclusions:

    • Drinking water perchlorate concentrations up to 100-120 µg/L do not appear to suppress thyroid function in newborns or school-age children.
    • The study does not support the hypothesis that environmental perchlorate exposure at these levels poses a risk to thyroid health in pediatric populations.
    • Further research may be warranted to explore the unexpected lower TSH levels observed in newborns in Taltal.