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[Cutaneous, hepatic and hematologic manifestations due to nevirapine: DRESS syndrome?]
D Sissoko1, F Ajana, X de la Tribonnière
1Service Régional Universitaire des Maladies infectieuses et du Voyageur, Tourcoing.
Background:
Manifestations similar to DRESS syndrome (drug rash with eosinophilia and systemic symptoms) may be induced by nevirapine.
Case Reports:
Three patients developed skin rash and general signs of liver dysfunction during the first 5 weeks after starting nevirapine. Laboratory tests showed elevated eosinophil counts and signs of inflammation simulating severe infection.
Discussion:
The incidence of DRESS syndrome is probably underestimated. No standard treatment has been proposed. In our 3 patients, parenteral corticosteroid therapy was successful, leading to a rapidly favorable clinical course although liver tests took longer to return to normal.
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