Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treatment margins for prostate brachytherapy.

B Han1, K Wallner, S Aggarwal

  • 1Department of Radiation Oncology, University of Washington, Seattle, USA.

Seminars in Urologic Oncology
|June 30, 2000
PubMed
Summary

Determining the optimal treatment margin (TM) for prostate brachytherapy is challenging due to unpredictable prostate volume changes after Iodine-125 implantation. Current 5mm margins may not consistently ensure adequate cancer-killing doses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Somatic and immune profiling of chemotherapy-associated aplastic anemia: a comparison with primary aplastic anemia and cancer without aplastic anemia].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2026
Same author

Navigation-assisted transoral endoscopic surgery for mandibular ramus-condyle tumours.

International journal of oral and maxillofacial surgery·2026
Same author

Sustained-Release RANKL Microneedles for Safe Orthodontic Acceleration.

Journal of dental research·2026
Same author

[Clinicopathological characteristics and prognostic significance of steatotic hepatocellular carcinoma with HBV-related cirrhosis: a propensity score-matched study].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

[Navigating pathological assessment of neoadjuvant hormonal therapy for prostate cancer: from clinical challenges to future directions].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same author

[Efficacy and safety of romiplostim N01 for refractory aplastic anemia: a retrospective single-center study].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2026

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Urology

Background:

  • Prostate brachytherapy utilizes radioactive seed implantation for cancer treatment.
  • Accurate dose delivery depends on precise targeting and accounting for anatomical changes.
  • Prostate volume can significantly change post-implantation due to edema and seed migration.

Purpose of the Study:

  • To evaluate the adequacy of planned treatment margins (TMs) in accounting for prostate volume changes after Iodine-125 ((125)I) brachytherapy.
  • To determine if a specific TM can ensure a sufficient periprostatic cancer-icidal dose despite post-implant volume variations.

Main Methods:

  • Studied 20 patients undergoing (125)I prostate implantation (144 Gy prescription dose).
  • Calculated treated volume (TV) based on the 144 Gy isodose distribution.

Related Experiment Videos

  • Measured distances between the gross tumor volume (GTV) and TV using post-implant CT scans to assess TMs.

    • Main Results:

    • Pre-implant TV was significantly larger than GTV (median 73 mL vs. GTV).
    • Planned TMs varied widely between patients, with a median of 3 mm.
    • A weak correlation was found between planned and post-implant TMs, influenced by unpredictable volume changes.

    Conclusions:

    • The significant and variable prostate volume changes post-(125)I implantation challenge the effectiveness of fixed planned treatment margins.
    • The unpredictable nature of these dimensional changes makes it difficult to establish optimal, universally applicable TMs for ensuring adequate target coverage.
    • Further research is needed to refine margin strategies in prostate brachytherapy.