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Colonic melanoma, primary or regressed primary.

S H Poggi1, J F Madison, W J Hwu

  • 1Section of Surgical Oncology, Yale School of Medicine, New Haven, Connecticut 06520-8062, USA.

Journal of Clinical Gastroenterology
|June 30, 2000
PubMed
Summary

Primary colonic melanoma, a rare gastrointestinal cancer, was diagnosed in a 79-year-old man. Surgical resection led to a 5-year disease-free survival, highlighting successful treatment for this unusual malignancy.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Primary melanoma of the colon is an exceptionally rare malignancy, with most gastrointestinal melanomas occurring in the anus or rectum.
  • This case report focuses on a solitary colonic melanoma, a condition with limited documented instances.

Observation:

  • An 8 x 5-cm tan-pink mass with central necrosis was surgically excised from the cecum of a 79-year-old male patient.
  • Histopathological examination revealed sheets of pigmented cells positive for S100 and HMB-45, infiltrating the bowel wall from an ulcerated mucosal surface.

Findings:

  • The patient had no history or evidence of cutaneous or ocular melanoma, supporting a primary colonic origin.
  • Immunohistochemistry confirmed the neoplastic cells expressed markers typical of melanoma (S100 and HMB-45).

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Implications:

  • The successful surgical management and prolonged disease-free survival in this case offer valuable insights into the prognosis and treatment of primary colonic melanoma.
  • This case underscores the importance of thorough histopathological evaluation for diagnosing rare gastrointestinal neoplasms.