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Anthraquinone-oligodeoxynucleotide conjugates as inhibitors of gene transcription
V Gibson1, R J Anderson, J A Hartley
1Institute of Pharmacy and Chemistry, University of Sunderland, UK.
The Journal of Pharmacy and Pharmacology
|June 30, 2000
Abstract:
Several anthraquinone-oligodeoxynucleotide conjugates have been synthesized and their inhibition of transcription of the bla gene in E. coli has been determined. All conjugates at 10 microM inhibited transcription and three conjugates inhibited mRNA production by 40 to 50% for periods of up to 60 min.