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Long-term results and multivariate analysis of prognostic factors in 138 consecutive patients operated on for Crohn's
M Cristaldi1, G M Sampietro, P G Danelli
1Division of General Surgery, Università degli Studi di Milano, Istituto di Scienze Biomediche, Ospedale Luigi Sacco, Milan, Italy.
Background:
Conservative surgery has become accepted as a useful option for the surgical treatment of complicated Crohn's disease (CD).
Methods:
One hundred thirty-eight consecutive patients treated with strictureplasty or miniresections for complicated CD have been observed prospectively. The possible influence of a number of variables on the risk of recurrence was investigated using the Cox proportional hazard model, and a time-to-event analysis was made using the Kaplan-Meier function.
Results:
There was no perioperative mortality; the morbidity rate was 5.7%. A close correlation was found between the risk of recurrence and the time between diagnosis and first surgery. The overall 5-year recurrence rate was 24%, being 36% in the patients requiring surgery within 1 year of diagnosis and 14% in those operated on more than 1 year after diagnosis.
Conclusions:
Risk factor analysis highlighted a group of patients at high risk of surgical recurrence. Given that our results are similar to those reported in other series, we consider strictureplasty and miniresections safe and effective procedures for the treatment of complicated CD.
