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Related Experiment Videos

Do thyroid hormones function in insects?

K G Davey1

  • 1Department of Biology, York University, M3J 1P3, Toronto, Ont., Canada. davey@yorku.ca

Insect Biochemistry and Molecular Biology
|July 6, 2000
PubMed
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Thyroid hormones, specifically 3,3

Area of Science:

  • Insect endocrinology
  • Molecular biology
  • Comparative physiology

Background:

  • Phenoxy-phenyl compounds and thyroxine mimic juvenile hormone III (JH III) in locust follicle cells.
  • 3,3',5-triiodothyronine (T3) is as effective as JH III and shares its receptor and pathway.
  • Other thyroxine derivatives show varying activities.

Purpose of the Study:

  • To investigate the activity of different thyroxine derivatives on locust follicle cells.
  • To elucidate the mechanism of T3 uptake and action.
  • To explore the role of thyroid hormones in locust reproduction.

Main Methods:

  • In vitro exposure of locust follicles to rhodamine-conjugated T3.
  • Inhibition studies using cycloheximide, low temperature, JH I, and specific antiserum.

Related Experiment Videos

  • Deiodinase inhibition assays with 6-n-propyl-2-thiouracil and aurothioglucose.
  • Measurement of T3 and thyroxine immunoreactivity in locust hemolymph and food.

    • Main Results:

    • T3 and T2 show significant activity, with T2 being more potent than JH III.
    • T3 enters follicle cells via receptor-mediated endocytosis and is potentially converted to a more active form.
    • T3 action is inhibited by deiodinase inhibitors and shows time-dependent activity, unlike T2.
    • Thyroid hormones are present in locust hemolymph and food, with titers varying during the reproductive cycle.

    Conclusions:

    • Thyroid hormones, particularly T3, are actively taken up by locust follicle cells and influence their function.
    • Thyroid hormones may act as signaling molecules in locust reproduction, potentially ingested and utilized by the insects.
    • The findings suggest a novel role for thyroid hormones in insect endocrinology, distinct from their known roles in vertebrates.