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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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[Gardner syndrome--on the basis of three cases]

A Joób-Fancsaly1, L Pataky, K Martonffy

  • 1Altalános Orvostudományi Kar, Szájsebészeti és Fogászati Klinika, Semmelweis Egyetem, Budapest.

Orvosi Hetilap
|July 6, 2000
PubMed

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...