Related Experiment Video

Updated: Jul 25, 2026

Transuterine Fetal Tracheal Occlusion Model in Mice
06:31

Transuterine Fetal Tracheal Occlusion Model in Mice

Published on: February 5, 2021

Double-layered manubrium sterni in young children with diastrophic dysplasia

G Currarino1

  • 1Department of Radiology, Texas Scottish Rite Hospital for Children, Dallas 75219, USA.

Pediatric Radiology
|July 6, 2000
PubMed

Insights

Diastrophic dysplasia can cause a rare manubrium anomaly in children, presenting as a double-layered sternum in infants and fusion in older children. This may stem from persistent embryonic midline structures.

Area of Science:

  • Pediatric Orthopedics
  • Skeletal Dysplasias
  • Embryology

Background:

  • Diastrophic dysplasia is a rare skeletal disorder affecting bone and cartilage development.
  • The sternum, particularly the manubrium, has a complex ossification process.
  • Anomalies of the manubrium are infrequently reported in pediatric populations.

Purpose of the Study:

  • To describe a specific sternal anomaly observed in children with diastrophic dysplasia.
  • To investigate the potential embryological origins of this manubrium abnormality.

Main Methods:

  • Retrospective review of lateral sternum roentgenograms.
  • Analysis of 12 pediatric patients diagnosed with diastrophic dysplasia.
  • Correlation of radiographic findings with patient age.

Main Results:

  • Four children (2 newborns, 2 aged 1.5 years) exhibited a double-layered manubrium with ventral accessory ossification.
  • Two older children (aged 5 and 11.5 years) showed manubrium deformity suggesting prior fusion of a ventral ossification center.
  • The anomaly appears to be age-dependent, with fusion occurring over time.

Conclusions:

  • A double-layered manubrium may be an unrecognized feature of diastrophic dysplasia.
  • The findings suggest a possible persistence and ossification of a primitive embryonic midline structure.
  • Further research into sternal embryology may clarify the etiology of this anomaly.

More Related Videos

Measuring Diaphragm Thickness and Function Using Point-of-Care Ultrasound05:51

Measuring Diaphragm Thickness and Function Using Point-of-Care Ultrasound

Published on: November 3, 2023

Diaphragmatic Ultrasound in Adults: Image Acquisition and Interpretation05:51

Diaphragmatic Ultrasound in Adults: Image Acquisition and Interpretation

Published on: January 31, 2025

Related Concept Videos

The Thoracic Cage: Sternum01:17

The Thoracic Cage: Sternum

The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid process.
The Thoracic Cage: Ribs01:20

The Thoracic Cage: Ribs

Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of all the ribs articulate with the T1–T12 thoracic vertebrae. In contrast,the anterior ends of most ribs attach to the sternum via their costal cartilages.
Parts of a Typical Rib
A typical rib has a head, neck, and body. The posterior end of the rib is called the head, followed by a narrow neck. The head articulates primarily with the costal facet...
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...