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[The effect of different infectious agents on the intensification of hematopoiesis during immunosuppression]
M R Karpova1, I F Zvereva, V V Novitskiĭ
1Siberian State Medical University, Research Institute of Pharmacology, Tomsk, Russia.
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|July 6, 2000
Abstract:
The action of Staphylococcus aureus, Escherichia coli and Herpes simplex virus on the hemopoiesis of mice with cytostatic myelosuppression was studied. The study revealed that the infection of the animals simultaneously with the action of cyclophosphamide considerably activated the processes leading to the restoration of hemopoiesis due to an increase in the mitotic activity of hemopoietic cells, the accelerated differentiation of hemopoietic precursor cells which could survive the cytostatic action and an increase in the functional activity of the hemopoiesis-producing microenvironment.