An ABC of drug-related problems
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Updated: Oct 15, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
R H Meyboom1, M Lindquist, A C Egberts
1Netherlands Pharmacovigilance Foundation LAREB, MH's-Hertogenbosch, The Netherlands. R.Meyboom@who-umc.org
Abstract:
The problems relating to the use of medicines are manifold. They may differ in pharmacological, pathological, epidemiological and legal respects, and may have different consequences, for example, as regards scientific study, regulation or rational use. Pharmacovigilance is concerned with all such problems: adverse effects and interactions as well as problems relating to ineffectiveness, inappropriate use, counterfeiting, dependence or poisoning. Practically all medicine-related problems can be classified in one basic system, taking into account their characteristics and distinctions. This system distinguishes between appropriate and inappropriate drug use; dose-related and dose-unrelated problems [corrected]; and types A ('drug actions'), B ('patient reactions') and C ('statistical') adverse effects. This classification may serve as an educational tool and may be useful in when choosing a study method and for the design of effective strategies in pharmacovigilance.
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