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Related Experiment Videos

Fluoroquinolone-induced renal failure.

B M Lomaestro1

  • 1Albany Medical Center Hospital, New York 12208, USA. lomaesb@mail.amc.edu

Drug Safety
|July 6, 2000
PubMed
Summary
This summary is machine-generated.

Fluoroquinolones, while generally safe, can rarely cause serious kidney damage. This review examines rare cases of fluoroquinolone-induced nephrotoxicity, including various forms of kidney injury.

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Area of Science:

  • Pharmacology
  • Nephrology
  • Antimicrobial Research

Background:

  • Fluoroquinolones are widely used, clinically effective antimicrobials.
  • Other antimicrobial classes are known to cause various forms of kidney toxicity.
  • Rare but serious kidney adverse effects associated with fluoroquinolones warrant investigation.

Purpose of the Study:

  • To review and highlight rare, potentially serious kidney adverse effects of fluoroquinolones.
  • To ascertain the incidence and features of fluoroquinolone-induced nephrotoxicity.
  • To analyze available data on kidney injury associated with specific fluoroquinolone agents.

Main Methods:

  • Conducted a Medline search from 1985 to May 1999.
  • Included fluoroquinolone agents: ciprofloxacin, norfloxacin, levofloxacin, ofloxacin, trovafloxacin, enoxacin, sparfloxacin, grepafloxacin, gatifloxacin, clinafloxacin, and moxifloxacin.

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  • Focused on case reports and temporally related events of nephrotoxicity.

    • Main Results:

    • Identified rare, potentially serious adverse effects involving the kidney.
    • Observed various forms of nephrotoxicity, including interstitial nephritis and tubular necrosis.
    • Data primarily consists of case reports, making incidence estimation difficult.
    • Ciprofloxacin use may be associated with an increased risk, potentially due to wider usage.

    Conclusions:

    • Fluoroquinolones, despite being generally well-tolerated, can rarely cause significant kidney damage.
    • The exact incidence and multifactorial causes of fluoroquinolone nephrotoxicity remain challenging to determine.
    • Further research is needed to fully understand and mitigate the risk of kidney injury from these antimicrobials.