The science of aging and the need for a mechanistic approach

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver.

Science advances·2020

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

Nature·2016

5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.

Oncogene·2012

Genome dynamics and transcriptional deregulation in aging.

Neuroscience·2006

BRCA1 gene sequence variation in centenarians.

Annals of the New York Academy of Sciences·2002

Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.

Journal of medical genetics·2001

MicroRNA-322 Promotes Granulosa Cell Senescence and Premature Ovarian Failure by Suppressing Klotho expression and Cell Cycle Progression.

Mechanisms of ageing and development·2026

Attenuating Monocytic Inflammaging via the miR-146a/TLR4 Axis: Characterization and Bioactivity of a Triterpenoid-Rich Callus Phytocomplex.

Mechanisms of ageing and development·2026

Metformin therapy increases leukocyte telomere length, telomerase activity, and longevity gene expression in Asian Indians with prediabetes: A 24-week participant-blind, outcome-assessor-blinded randomized controlled trial.

Mechanisms of ageing and development·2026

Homeostatic dysregulation and clocks: a distance-based perspective.

Mechanisms of ageing and development·2026

Ensemble DNA methylation clock demonstrates Immune-metabolic aging signatures associated with mortality.

Mechanisms of ageing and development·2026

Instrumental, neurophysiological, cognitive and sleep investigations into the high risk of neurodegeneration in late onset epilepsy of unknown aetiology: The INSIGHT-LOEU study.

Mechanisms of ageing and development·2026

Molecular Pathogenesis, Global Epidemiological Trends, and Treatment Strategies for Pteropine Orthoreoviruses: A Narrative Review.

Emerging microbes & infections·2026

Plastid genome evolution and phylogenomics with broad taxon sampling: insights into intrafamilial classification of Hamamelidaceae.

Frontiers in plant science·2026

Morphometric and spectral signatures reveal strong structure and localized gray zones in Microgramma species delimitation.

Annals of botany·2026

Resolving the "Yucca queretaroensis problem": Phylogenomic analysis of Yucca reveals the identity of an enigmatic species and the origin of an obligate pollination mutualism.

American journal of botany·2026

A Diagnostic Approach to Giant Cell Arteritis Initially Presenting with Infarction without Headache Using MR Vessel Wall Imaging and a Temporal Artery Biopsy: A Case Report.

Internal medicine (Tokyo, Japan)·2026

A plant-centric view of class B flavin-dependent monooxygenase evolution and diversity.

The Plant journal : for cell and molecular biology·2026

Related Experiment Videos

The science of aging and the need for a mechanistic approach

Related Concept Videos

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver.

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.

Genome dynamics and transcriptional deregulation in aging.

BRCA1 gene sequence variation in centenarians.

Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1.

MicroRNA-322 Promotes Granulosa Cell Senescence and Premature Ovarian Failure by Suppressing Klotho expression and Cell Cycle Progression.

Attenuating Monocytic Inflammaging via the miR-146a/TLR4 Axis: Characterization and Bioactivity of a Triterpenoid-Rich Callus Phytocomplex.

Metformin therapy increases leukocyte telomere length, telomerase activity, and longevity gene expression in Asian Indians with prediabetes: A 24-week participant-blind, outcome-assessor-blinded randomized controlled trial.

Homeostatic dysregulation and clocks: a distance-based perspective.

Ensemble DNA methylation clock demonstrates Immune-metabolic aging signatures associated with mortality.

Instrumental, neurophysiological, cognitive and sleep investigations into the high risk of neurodegeneration in late onset epilepsy of unknown aetiology: The INSIGHT-LOEU study.

Molecular Pathogenesis, Global Epidemiological Trends, and Treatment Strategies for Pteropine Orthoreoviruses: A Narrative Review.

Plastid genome evolution and phylogenomics with broad taxon sampling: insights into intrafamilial classification of Hamamelidaceae.

Morphometric and spectral signatures reveal strong structure and localized gray zones in Microgramma species delimitation.

Resolving the "Yucca queretaroensis problem": Phylogenomic analysis of Yucca reveals the identity of an enigmatic species and the origin of an obligate pollination mutualism.

A Diagnostic Approach to Giant Cell Arteritis Initially Presenting with Infarction without Headache Using MR Vessel Wall Imaging and a Temporal Artery Biopsy: A Case Report.

A plant-centric view of class B flavin-dependent monooxygenase evolution and diversity.

Related Experiment Videos

The science of aging and the need for a mechanistic approach

Related Concept Videos

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