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Related Experiment Videos

How much antibiotic suspension is enough?

L B Dusdieker1, J R Murph, G Milavetz

  • 1Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242-1083, USA. lois-dusdieker@uiowa.edu

Pediatrics
|July 6, 2000
PubMed
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Pharmacies frequently dispensed inadequate antibiotic suspension volumes, leading to missed doses. New prescription guidelines and improved patient counseling are recommended to ensure accurate medication dispensing.

Area of Science:

  • Pharmacology
  • Pharmacy Practice
  • Patient Safety

Background:

  • Pilot data indicate that pharmacies often dispense insufficient quantities of antibiotic suspensions.
  • Inadequate volumes can lead to missed patient doses and suboptimal treatment outcomes.

Purpose of the Study:

  • To assess the frequency of inadequate antibiotic suspension volumes dispensed by local pharmacies.
  • To develop prescription guidelines for ensuring adequate antibiotic volumes.
  • To evaluate the quality of pharmacist counseling regarding antibiotic dispensing.

Main Methods:

  • Sixty-one pharmacies dispensed penicillin potassium and trimethoprim-sulfamethoxazole prescriptions with instructions for a 10-day supply.
  • Dispensed volumes were measured, and the number of doses provided was calculated.

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  • Pharmacist verbal and written counseling practices were documented.

    • Main Results:

    • Significant variability in dispensed volumes for both penicillin potassium and trimethoprim-sulfamethoxazole was observed.
    • On average, dispensed volumes resulted in fewer doses than prescribed.
    • One-third of pharmacies failed to dispense a medication measuring device, and counseling was inconsistent.

    Conclusions:

    • Calculating required volume plus a 10-30% buffer is recommended for antibiotic suspensions.
    • Prescriptions should specify the need for a medication-measuring device.
    • Enhancing patient counseling and instructions is crucial for appropriate antibiotic use.