Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Turkish pepper (extra hot).

A Woywodt1, A Herrmann, M Choi

  • 1Department of Nephrology, Franz-Volhard-Clinic, Charité Campus Berlin-Buch, Humboldt-University, Berlin, Germany.

Postgraduate Medical Journal
|July 6, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Communication barriers in aftercare: a qualitative study of allogeneic stem cell transplant patients.

BMC cancer·2026
Same author

What makes physicians implement climate change and heat adaptation measures in outpatient practices? A mixed-methods study.

Public health·2025
Same author

First measurements of an imaging heavy ion beam probe at the ASDEX Upgrade tokamak.

The Review of scientific instruments·2024
Same author

Jejunal arteriovenous malformation and multiple acquired extrahepatic portosystemic shunts in a juvenile dog, presenting with melena.

The Journal of small animal practice·2023
Same author

Long-Time Diffusion in Polymer Melts Revealed by <sup>1</sup>H NMR Relaxometry.

ACS macro letters·2022
Same author

High-heat flux ball-pen probe head in ASDEX-Upgrade.

The Review of scientific instruments·2022
Same journal

Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials.

Postgraduate medical journal·2026
Same journal

Two cases of toxic epidermal necrolysis with severe ocular involvement treated with adjunctive tofacitinib.

Postgraduate medical journal·2026
Same journal

Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

Postgraduate medical journal·2026
Same journal

Care, cash, and proof: forensic accountability for war-related starvation.

Postgraduate medical journal·2026
Same journal

Response to traumatic injuries in polo players in England.

Postgraduate medical journal·2026
Same journal

Aids to venesection and parenteral drug administration in patients with difficult veins.

Postgraduate medical journal·2026
See all related articles

Excessive liquorice consumption can cause severe hypertension by mimicking aldosterone. Removing liquorice from the diet resolved the patient's high blood pressure, demonstrating its direct impact.

Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiology

Background:

  • Hypertension is a significant global health concern.
  • Secondary hypertension requires thorough investigation to identify underlying causes.
  • Aldosterone plays a key role in regulating blood pressure and electrolyte balance.

Observation:

  • A 38-year-old female presented with severe hypertension (250/110 mm Hg).
  • Initial evaluation excluded secondary causes of hypertension.
  • Laboratory findings revealed low plasma renin activity and reduced sodium excretion, suggesting an aldosterone-like effect.

Findings:

  • The patient's hypertension resolved after discontinuing consumption of liquorice candies.
  • This indicates that liquorice, specifically its glycyrrhizic acid component, can induce a state mimicking hyperaldosteronism.

Related Experiment Videos

  • The mechanism involves inhibition of the enzyme 11-beta-hydroxysteroid dehydrogenase type 2, which normally inactivates cortisol, leading to its mineralocorticoid effects.

    • Implications:

    • Dietary factors, even seemingly benign ones like candy, can significantly impact blood pressure.
    • Awareness of liquorice-induced hypertension is crucial for clinicians managing difficult-to-treat hypertension.
    • Patients with unexplained hypertension should be screened for excessive consumption of liquorice-containing products.