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Related Experiment Videos

ATP-dependent chromatin remodeling: going mobile.

C L Peterson1

  • 1Program in Molecular Medicine and Department of Biochemistry and Molecular Biology, Biotech 2, Suite 301, 373 Plantation St., 01605, Worcester, MA, USA. craig.peterson@umassmed.edu

FEBS Letters
|July 6, 2000
PubMed
Summary
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ATP-dependent chromatin remodeling enzymes use ATP hydrolysis to alter DNA structure, facilitating key cellular processes. Their biochemical properties and nucleosome movement mechanisms are reviewed.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • ATP-dependent chromatin remodelers are essential multi-subunit enzymes found in eukaryotes.
  • They play critical roles in DNA-mediated processes by altering chromatin structure.

Purpose of the Study:

  • To review the biochemical properties of ATP-dependent chromatin remodeling enzymes.
  • To discuss how ATP-driven nucleosome movements explain their diverse activities.

Main Methods:

  • Biochemical characterization of enzyme activity.
  • Analysis of chromatin structure disruption.
  • Review of existing literature on enzyme mechanisms.

Main Results:

  • These enzymes hydrolyze ATP at high rates (~1000 ATP/min).

Related Experiment Videos

  • ATP hydrolysis disrupts chromatin, leading to enhanced factor binding and altered DNA accessibility.
  • Observed effects include changes in DNase I cleavage patterns, nucleosome movement, and hypersensitive site generation.

    • Conclusions:

    • ATP-dependent chromatin remodelers are crucial for dynamic DNA processes.
    • Nucleosome repositioning driven by ATP hydrolysis is a unifying mechanism for their functions.