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Microembolus detections at follow-up in 19 patients with acute stroke: correlation with stroke etiology and

D W Droste1, M Ritter, V Kemény

  • 1Department of Neurology, University of Münster, Germany.

Cerebrovascular Diseases (Basel, Switzerland)
|July 6, 2000
PubMed

Insights

Microembolic signals (MES) detected in acute stroke patients varied significantly, with some experiencing recurrent events. These signals may indicate active, individual processes of healing or disruption in the acute stroke phase.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroimaging

Background:

  • Microembolic signals (MES) are indicators of embolic activity.
  • Understanding MES in acute stroke is crucial for prognosis and treatment.

Purpose of the Study:

  • To conduct follow-up transcranial Doppler (TCD) investigations for MES in acute stroke patients.
  • To correlate MES with stroke etiology and antithrombotic treatment.
  • To determine the solid nature of MES.

Main Methods:

  • Investigated 19 patients with middle cerebral artery ischemic events (16 stroke, 3 TIA) within 24h of symptom onset.
  • Performed six 1-hour TCD recordings on days 1, 2, 3, 4, 7, and 14 from the affected artery.
  • Utilized the four-gate technique and established MES identification criteria.

Main Results:

  • Eight of 19 patients showed MES, with high variability unrelated to time or treatment.
  • All 3 patients with internal carotid artery dissection had MES; none were detected in lacunar stroke patients.
  • Two MES-positive patients had recurrent TIAs; no recurrent events occurred in MES-negative patients.

Conclusions:

  • MES in acute stroke patients exhibit variable patterns, potentially reflecting dynamic embolic source activity.
  • The presence of MES may be associated with an increased risk of recurrent ischemic events.
  • Further research is needed to fully elucidate the nature and implications of MES in stroke.

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