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[Piperacillin: Use in a general hospital]

Nieto1, Porta, Besolí

  • 1Programa Asistencial de Patología Infecciosa, Corporació Sanitària Parc Taulí, 08208 Sabadell, Barcelona.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|July 6, 2000
PubMed
Summary

Piperacillin remains a key antibiotic for treating hospital-acquired infections, particularly in neutropenic patients and pneumonia. It shows continued effectiveness against Pseudomonas aeruginosa.

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Hospital Pharmacy

Background:

  • Piperacillin is a widely used beta-lactam antibiotic.
  • Its efficacy and indications in general hospital settings require ongoing evaluation.
  • Understanding antibiotic usage patterns is crucial for antimicrobial stewardship.

Purpose of the Study:

  • To retrospectively analyze the utilization of piperacillin in a general hospital.
  • To identify the primary therapeutic indications for piperacillin use.
  • To assess treatment outcomes and microbiological data associated with piperacillin therapy.

Main Methods:

  • Retrospective data collection from 338 patients treated with piperacillin between January 1996 and December 1997.
  • Analysis of 385 infectious episodes, including patient demographics, diagnoses, and treatment regimens.

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  • Microbiological data including culture sources and identified pathogens were reviewed.

    • Main Results:

    • Neutropenic infections (39.2%) and nosocomial infections were primary indications.
    • Piperacillin was frequently combined with aminoglycosides (86.2%).
    • Gram-negative bacilli, including Pseudomonas aeruginosa and Escherichia coli, were common pathogens.

    Conclusions:

    • Piperacillin is indicated for neutropenic infections and nosocomial pneumonia.
    • The antibiotic demonstrates sustained activity against Pseudomonas aeruginosa.
    • Piperacillin remains a valuable therapeutic option in general hospital settings.