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Cell death: a trigger of autoimmunity?

R J Rodenburg¹, J M Raats, G J Pruijn

¹Department of Biochemistry, University of Nijmegen, The Netherlands.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|July 6, 2000

Summary

Systemic autoimmune diseases involve antibodies targeting self-antigens. Autoantigens are often modified during cell death, suggesting this process initiates the immune response in autoimmunity.

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Area of Science:

Immunology
Cell Biology
Autoimmunity

Background:

Systemic autoimmune diseases feature antibodies against self-antigens.
Emerging evidence links autoantigen modification during cell death to autoimmunity.

Purpose of the Study:

To review modifications of autoantigens during cell death.
To explore the role of dying cell components in initiating autoimmune responses.

Main Methods:

Literature review of studies on autoantigen modification.
Analysis of data connecting cell death pathways to autoantigen presentation.

Main Results:

A significant number of autoantigens undergo modification during cellular demise.
These modifications may serve as triggers for the immune system in autoimmune conditions.

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Conclusions:

Modification of autoantigens during cell death is a key factor in autoimmunity.
The immune response to dying cell components is a central hypothesis in autoimmune disease development.