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[Computer databases on cancer-related genes].

N Shimizu1, S Minoshima

  • 1Department of Molecular Biology, School of Medicine, Keio University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 6, 2000
PubMed
Summary
This summary is machine-generated.

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KMcancerDB is a new database compiling 1261 cancer gene mutation data across 9 organs. This resource, powered by MutationView software, aids cancer research by providing accessible graphical data analysis online.

Area of Science:

  • Genomics
  • Bioinformatics
  • Cancer Research

Context:

  • Cancer research relies on comprehensive mutation data for gene discovery and therapeutic target identification.
  • Existing databases may lack integrated graphical analysis tools or specific cancer gene mutation data.
  • The Keio Mutation DataBase for cancer-related genes (KMcancerDB) addresses these limitations.

Purpose:

  • To develop and present KMcancerDB, a novel database for compiling and analyzing cancer-related gene mutations.
  • To utilize the custom-designed MutationView software for data compilation and network-based graphical presentation.
  • To integrate information from the Online Mendelian Inheritance in Man (OMIM) database.

Summary:

  • KMcancerDB houses 1261 mutation datasets for genes implicated in cancers across 9 distinct organs/tissues.

Related Experiment Videos

  • The database employs MutationView software, enabling data compilation and network visualization via standard web browsers.
  • It incorporates data from OMIM, enhancing its utility for studying genetic factors in human diseases.

    • Impact:

    • Provides a centralized, accessible resource for researchers studying cancer genetics.
    • Facilitates advanced data analysis and visualization of mutation patterns through a web interface.
    • Supports the identification of novel cancer-related genes and potential therapeutic strategies.