Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[DNA vaccines against allergy].

Y Sato¹, R Kasukawa

¹Department of Internal Medicine II, Fukushima Medical University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|July 6, 2000

Summary

DNA vaccines, utilizing immunostimulatory DNA sequences (ISS), can shift immune responses from Th2 to Th1. This mechanism shows promise for treating allergic diseases like asthma by reducing allergen-specific IgE and lung eosinophils.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ultrasonographic evaluation of knee joint synovitis in two patients with palindromic rheumatism.

Modern rheumatology·2014

Same author

Ultrasonographic evaluation of synovial effusion and synovial proliferation pattern in the knee joints of patients with rheumatoid arthritis.

Modern rheumatology·2014

Same author

Usefulness of endoscopic ultrasonographic analysis of variceal hemodynamics for the treatment of esophageal varices.

Fukushima journal of medical science·2002

Same author

A patient with Wegener's granulomatosis with initial clinical presentations of Henoch-Schönlein purpura.

Internal medicine (Tokyo, Japan)·2001

Same author

An ancient lectin-dependent complement system in an ascidian: novel lectin isolated from the plasma of the solitary ascidian, Halocynthia roretzi.

Journal of immunology (Baltimore, Md. : 1950)·2001

Same author

Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo acid dehydrogenase complex.

Journal of hepatology·2001

Area of Science:

Immunology
Vaccinology
Molecular Biology

Context:

DNA vaccines leverage immunostimulatory DNA sequences (ISS) containing unmethylated CpG motifs.
These sequences promote a T-helper-1 (Th1)-biased immune response.
Th1 responses are known to modulate ongoing T-helper-2 (Th2) immune responses.

Purpose:

To explore the therapeutic potential of DNA vaccines for allergic diseases, specifically allergy and asthma.
To investigate if DNA vaccination can modify existing Th2-biased immune responses characteristic of allergies.

Summary:

DNA vaccination in murine models, using plasmid DNA encoding an allergen, effectively reduced pre-existing IgE responses.
Vaccination also led to a significant decrease in eosinophil levels in the lungs following allergen challenge.
These findings demonstrate the ability of DNA vaccines to counteract key allergic inflammatory markers.

Impact:

DNA vaccines represent a promising novel therapeutic strategy for managing allergic diseases.
The Th1-promoting adjuvant effect of ISS in DNA vaccines offers a new avenue for allergy and asthma treatment.
Further development could lead to widely appreciated applications for patients suffering from allergic conditions.

Related Experiment Videos