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Advantages and disadvantages of trial designs: a review of analysis methods for ICD studies. AVID Investigators
A P Hallstrom1, J L Anderson, L A Cobb
1Department of Biostatistics, University of Washington, Seattle 98105, USA. aph@u.washington.edu
Abstract:
General modalities of analyses that have been used for ICD studies are reviewed. Published "typical" examples are briefly described. The historical cohort method is exemplified with previously unpublished data from the Seattle Cardiac Arrest Survivor database. The AVID Study database is used to compare the results obtained from nonrandomized methodologies with randomized methodologies. Particular issues related to the use of the ICD for example, mode of death, inability to blind, selection practice, and treatment decision times make this a natural pedagogic platform.
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