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Identification of the UV-responsive sequence in the human tissue plasminogen activator gene
J Fujiwara1, M Fujii, M Shimoda
1AISIN Cosmos R&D CO., Ltd., Kazusa Incubation Center, Yana Kisarazu, Chiba, Japan.
Bioscience, Biotechnology, and Biochemistry
|July 6, 2000
Abstract:
Functional analysis of regulatory elements in the human tissue plasminogen activator (tPA) gene showed that its promoter (-119/+169) is activated by UV irradiation in HeLa cells. We demonstrated here that the AP-2 like CCCCACCC sequence is involved in the UV-mediated activation and Sp1 binds to the sequence.