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Processing glucosidase inhibition by 1-azafagomine
1Animal and Cellular Systems Laboratory, RIKEN (The Institute of Physical and Chemical Research), Wako-shi, Saitama, Japan.
Bioscience, Biotechnology, and Biochemistry
|July 6, 2000
Abstract:
Natural azasugars have the ring oxygen substituted by nitrogen. They show potent inhibitory activity against glycosidases. The effect of substituting the ring carbon with nitrogen was examined with 1-azafagomine. 1-Azafagomine exhibited similar activity against processing glucosidase to that of fagomine.