Setting safe acute exposure limits for halon replacement chemicals using physiologically based pharmacokinetic

A Vinegar1, G W Jepson, M Cisneros

  • 1AFRL/HEST, ManTech Environmental Technology, Inc., Wright-Patterson Air Force Base, PO Box 31009, Dayton, OH 45437, USA. allen.vinegar@he.wpafb.af.mil

Summary

New fire suppressants, like Halon 1301 replacements, are evaluated for cardiac sensitization risks. Physiologically based pharmacokinetic (PBPK) modeling helps establish safe exposure limits for these critical fire safety chemicals.

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