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Related Experiment Videos

Angiogenesis in the mouse lung.

W Mitzner1, W Lee, D Georgakopoulos

  • 1Department of Medicine and Environmental Health Sciences, The Johns Hopkins University, Baltimore, MD 21205, USA. wmitzner@jhsph.edu

The American Journal of Pathology
|July 6, 2000
PubMed
Summary
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Mice can develop new blood vessels in their lungs after pulmonary artery obstruction. This compensatory angiogenesis bypasses normal routes and mimics tumor vascularization, offering a unique research model.

Area of Science:

  • Cardiovascular Biology
  • Pulmonary Medicine
  • Angiogenesis Research

Background:

  • Obstructed pulmonary arterial blood flow typically triggers compensatory bronchial vasculature growth in mammals.
  • This systemic angiogenesis is crucial in pulmonary vascular disease and lung cancer, as tumors often rely on systemic circulation.
  • Unlike larger species, mouse bronchial vasculature does not typically extend into intraparenchymal airways.

Purpose of the Study:

  • To investigate the potential for generating a functional bronchial circulation in mice.
  • To model the unique vascularization patterns observed in lung tumors.
  • To understand compensatory angiogenesis in the absence of hypoxia.

Main Methods:

  • Inducing a 40% permanent obstruction of the pulmonary circulation via left pulmonary artery ligation in mice.

Related Experiment Videos

  • Quantifying systemic blood flow to the lung using fluorescent microspheres over 3 months post-ligation.
  • Analyzing the origin and development of newly formed vasculature.

    • Main Results:

    • A significant systemic blood flow to the lung, up to 15% of normal pulmonary flow, was generated within 5-6 days post-ligation.
    • Newly developed angiogenic vessels did not originate from the extraparenchymal bronchial circulation.
    • A novel vasculature developed between the visceral and parietal pleurae, supplied by intercostal arteries.

    Conclusions:

    • Pulmonary artery obstruction in mice can induce a unique, non-hypoxia-driven angiogenesis.
    • This process creates a new vascular pathway directly into the lung, bypassing traditional routes.
    • The induced angiogenesis mimics the systemic vascular supply of many lung tumors, providing a valuable model for study.